You can serve VuFind using Nginx as an alternative to Apache.

This example configuration was shared by Sascha-Oliver Prolic.

server {

    listen 80;
    root /path/to/vufind2/public;
    index index.html index.htm index.php;

    server_name your-server-name;

    location / {
        try_files $uri $uri/ /index.php$is_args$args;
      }

    location ~ ^/themes/([0-9a-zA-Z-_]*)/css/(.*)$ {
      default_type text/css;
      alias /path/to/vufind2/themes/$1/css/$2;
    }

    location ~ ^/themes/([0-9a-zA-Z-_]*)/images/(.*)$ {
      alias /path/to/vufind2/themes/$1/images/$2;
    }

    location ~ ^/themes/([0-9a-zA-Z-_]*)/js/(.*)$ {
      alias /path/to/vufind2/themes/$1/js/$2;
    }

    location ~ \.php$ {
                fastcgi_param VUFIND_ENV development;
                fastcgi_param APPLICATION_ENV development;
                fastcgi_param VUFIND_HOME /path/to/vufind2;
                fastcgi_param VUFIND_LOCAL_DIR /path/to/vufind2/local;
                fastcgi_param VUFIND_LOCAL_MODULES your-module-name;
                fastcgi_pass 127.0.0.1:9000;
                fastcgi_index index.php;
                include fastcgi_params;
    }
}